Abstract
We have calculated the spatial distribution of absorbed light energy within layers of a mucous tissue that contains photosensitizer methylene blue. Under irradiation regimes that are typical of antimicrobial photodynamic therapy (laser radiation wavelength, 670 nm; power density, 150–300 mW/cm2; dose, 9–18 J/cm2), we have analyzed conditions that are necessary for the light penetration and delivery of methylene blue to a nidus of infection on a mucosal surface. We have performed a computer simulation of thermal fields, estimated maximal heating temperatures, and considered the degree at which the heating affects the trans-mission of light through a stained tissue.
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