Abstract
Objective To evaluate the effect of antimicrobial photodynamic therapy (PDTa) on the treatment of chemotherapy-induced mucositis in pediatric patients. Study Design It was a pilot study of an open, controlled, and blind randomized clinical trial conducted with 29 patients, with ages ranging from 10 months to 18 years, who were divided into 2 groups. Group A was submitted to PDTa with 0.01% methylene blue and red laser with 3 J energy per point; group B was submitted to photobiomodulation with wavelength of 660 nm and 1 J energy per point. The chi-square, Fisher exact, Student's t, and Mann-Whitney tests and the mixed linear regression model were used for comparison between the groups, with the maximum error admitted of 5%. Results There was no difference between the groups regarding the number of sessions necessary for clinical cure of the oral lesions (P = .95) or reduction in pain (P = .26; P = .49). Within each group, however, there was significant reduction in pain (P = .03; P = .003). Conclusion PDTa could be used for control of oral mucositis in children/young patients. It was well tolerated and presented satisfactory results, the same as photobiomodulation in reducing pain associated with the mucositis.
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