Abstract
Mucormycosis is an extremely aggressive fungal disease that has a high mortality rate. Conventional treatment consists of high doses of antibiotics and antifungal agents associated with surgical resections, but even with this aggressive treatment, the mortality rate is still high. The antimicrobial photodynamic therapy (aPDT), also called photodynamic inactivation (PDI), it is an interesting alternative to antifungal therapy because it has non-specific biological site action and can also be an additional method of treatment in conjunction with surgery and antifungal therapy. In this work we studied the evaluation of the photodynamic antimicrobial response in different phases of fungus growth (conidium and hyphae in the white and black phases) and for different protocols of PDI with PDZ, varying the concentration of photosensitizer, the incubation time, the association with surfactant and the fluence of light at 660 nm. In this work, PDI showed great potential in the in vitro study of R. oryzae.
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