Abstract
Antimicrobial peptides targeting bacterial ribosome.
Highlights
Antibiotics kill bacteria by inhibiting vital enzymes involved in cellular metabolism, including protein production
We and our colleagues revealed the mechanism used by the proline-rich antimicrobial peptide (PrAMP) Oncocin (Onc112) to inhibit bacterial protein synthesis [1, 2]
This mechanism illuminates a strategy, which has been conserved throughout evolution and is used by plants and animals against the ability of microorganisms to develop resistance. It inactivates protein synthesis in a clever manner: its binding site overlaps with three functional sites of the bacterial ribosome, limiting dramatically the probability of appearance of resistance mutations
Summary
Antibiotics kill bacteria by inhibiting vital enzymes involved in cellular metabolism, including protein production. We and our colleagues revealed the mechanism used by the proline-rich antimicrobial peptide (PrAMP) Oncocin (Onc112) to inhibit bacterial protein synthesis [1, 2]. It inactivates protein synthesis in a clever manner: its binding site overlaps with three functional sites of the bacterial ribosome, limiting dramatically the probability of appearance of resistance mutations.
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