Abstract

Antimicrobial peptides targeting bacterial ribosome.

Highlights

  • Antibiotics kill bacteria by inhibiting vital enzymes involved in cellular metabolism, including protein production

  • We and our colleagues revealed the mechanism used by the proline-rich antimicrobial peptide (PrAMP) Oncocin (Onc112) to inhibit bacterial protein synthesis [1, 2]

  • This mechanism illuminates a strategy, which has been conserved throughout evolution and is used by plants and animals against the ability of microorganisms to develop resistance. It inactivates protein synthesis in a clever manner: its binding site overlaps with three functional sites of the bacterial ribosome, limiting dramatically the probability of appearance of resistance mutations

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Summary

Introduction

Antibiotics kill bacteria by inhibiting vital enzymes involved in cellular metabolism, including protein production. We and our colleagues revealed the mechanism used by the proline-rich antimicrobial peptide (PrAMP) Oncocin (Onc112) to inhibit bacterial protein synthesis [1, 2]. It inactivates protein synthesis in a clever manner: its binding site overlaps with three functional sites of the bacterial ribosome, limiting dramatically the probability of appearance of resistance mutations.

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