Abstract
Novel antibiotics based on membrane-active antimicrobial peptides (AMPs) are promising candidates for defending the spread of diseases caused by multi-resistant pathogenic bacteria. Notwithstanding the number of works that explore the relationship between AMP activity and membrane architecture, the dynamics and full mechanism that lead to cell death are currently not clear. This prompted us to investigate the cinematographic effects of human lactoferricin derivatives on live E. coli using high-resolution small-angle X-ray and neutron scattering (USAXS/SAXS - VSANS/SANS) measurements and complementary techniques.
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