Antimicrobial peptides from freshwater invertebrate species: potential for future applications.

Abstract

Invertebrates are a significant source of antimicrobial peptides because they lack an adaptive immune system and must rely on their innate immunity to survive in a pathogen-infested environment. Various antimicrobial peptides that represent major components of invertebrate innate immunity have been described in a number of investigations over the last few decades. In freshwater invertebrates, antimicrobial peptides have been identified in arthropods, annelids, molluscs, crustaceans, and cnidarians. Freshwater invertebrate species contain antimicrobial peptides from the families astacidin, macin, defensin, and crustin, as well as other antimicrobial peptides that do not belong to these families. They show broad spectrum activities greatly directed against bacteria and to a less extent against fungi and viruses. This review focuses on antimicrobial peptides found in freshwater invertebrates, highlighting their features, structure-activity connections, antimicrobial processes, and possible applications in the food industry, animal husbandry, aquaculture, and medicine. The methods for their synthesis, purification, and characterization, as well as the obstacles and strategies for their development and application, are also discussed.