Abstract
Recently, antimicrobial peptides (AMPs) have emerged as a promising anticancer remedy. Negative charge of the bacterial membranes gives some measure for selectivity of cationic AMPs, since mammalian cell membranes are largely zwitterionic. Accumulating evidence indicates that lipid composition of the cancer cell membranes is different from a healthy cell, displaying net membrane surface negative charge. Understanding the nature of the negatively charged membrane domains could provide a new basis for anticancer therapy drug design using antimicrobial peptides or their synthetic mimics.
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