Abstract
The aim of this study was to develop a biocompatible coating for wound dressings, containing iron oxide nanoparticles functionalized with patchouli essential oil in order to obtain improved antimicrobial properties able to prevent biofilm development and consecutive associated infections. The bioactive coating was prepared by the co-precipitation of a precursor in an alkaline solution of patchouli oil. The prepared surface was characterized by XRD (X ray diffraction), TEM (transmission electron microscopy), SAED (selected area diffraction), SEM (scanning electron microscopy) and FT-IR (Fourier transform infrared spectroscopy). The bioevaluation of the obtained coating consisted in antimicrobial, as well as in vitro and in vivo biocompatibility and biodistribution assays. The obtained coating revealed a strong anti-biofilm activity maintained up to 72 h, as well as a low cytotoxicity on mammalian cells and a good biodistribution after intraperitoneal injection in mice. These results demonstrate the promising potential of the respective coatings for the management of wound infections and for the development of soft materials with improved resistance to microbial colonization.
Highlights
IntroductionWound infections are commonly caused by microbial biofilms developed on the damaged tissues, which due to the pro-inflammatory induced response delay the normal progression of healing requiring
3 4 seen from Transmissionelectron electronmicroscopy microscopy (TEM) images that nanoparticles are nearly spherical with an average diameter of 7.5 nm, which is in concordance with the results obtained from
The particles are presented as clusters seen from TEM images that nanoparticles are nearly spherical with an average diameter of 7.5 nm, which is in concordance with the results obtained from XRD
Summary
Wound infections are commonly caused by microbial biofilms developed on the damaged tissues, which due to the pro-inflammatory induced response delay the normal progression of healing requiring. Wound infections are commonly caused by microbial biofilms developed on the damaged tissues, which due to the pro‐inflammatory induced response delay the normal progression of longer periods of care and periods more complex treatment regimens, increasing treatment cost and healing requiring longer of care and more complex treatment regimens,the increasing the negatively impact the life quality of the affected patients [1,2,3].
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