Abstract
A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.
Highlights
The importance and application of Schiff bases has attracted an enormous research interests in the synthesis of metal-based compounds[1,2,3]
The synthesized Schiff bases and their metal chelates have been screened for their bactericidal/ fungicidal activity against a number of bacterial/fungal strains and results have been reported
The newly synthesized Schiff bases acted as tridentate ligands for chelation with the Co(II), Cu(II), Ni(II) and Zn(II) metal atoms
Summary
The importance and application of Schiff bases has attracted an enormous research interests in the synthesis of metal-based compounds[1,2,3]. Many Schiff bases have been reported[4] to possess significant biological properties such as anti-microbial[5], anti-bacterial[6], anti-fungal[7], anti-tumor[8], anti-inflammatory[9], anti-HIV10, anti-convulsant[11], anti-cancer[12,13], anti-malarial[14], antiviral[15] and as an analgesic[16]. Due to significant structural properties and applications of metals-based compounds in bioactivities, we wish to report a new class of antibacterial and antifungal thiophene derived Schiff bases, N-[(1E)-1-(thiophen-2-yl)ethylidene]ethane-1, 2-diamine (L1), N-[(1E)-1-(thiophen-2-yl) ethylidene]propane-1, 3-diamine (L2) and N-[(1E)-1-(thiophen-2-yl) ethylidene]butane-1,4diamine (L3) (Scheme 1) and their Co(II), Cu(II), Ni(II) and Zn(II) metal chelates (1)–(12) (Scheme 2). The synthesized Schiff bases and their metal chelates have been screened for their bactericidal/ fungicidal activity against a number of bacterial/fungal strains and results have been reported.
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