Abstract
Recent advances in the development of biomaterials have given rise to new options for surgery. New-generation medical devices can control chemical breakdown and resorption, prevent post-operative adhesion, and stimulate tissue regeneration. For the fabrication of medical devices, numerous biomaterials can be employed, including non-degradable biomaterials (silicone, polypropylene, expanded polytetrafluoroethylene) or biodegradable polymers, including implants and three-dimensional scaffolds for tissue engineering, which require particular physicochemical and biological properties. Based on the combination of new generation technologies and cell-based therapies, the biocompatible and bioactive properties of some of these medical products can lead to progress in the repair of injured or harmed tissue and in tissue regeneration. An important aspect in the use of these prosthetic devices is the associated infection risk, due to the medical complications and socio-economic impact. This paper provides the latest achievements in the field of antimicrobial surgical meshes for hernia repair and discusses the perspectives in the development of these innovative biomaterials.
Highlights
Based on the combination of new generation technologies and cell-based therapies, the biocompatible and bioactive properties of medical products can lead to progress in repairing injured or harmed tissues and in tissue regeneration
A comparison between eight different commercial hernia meshes with different characteristics, based on commonly used polymers (PP, expanded polytetrafluoroethylene (ePTFE), and condensed polytetrafluoroethylene (cPTFE)) has shown that ePTFE
The in vitro studies evaluated the performance of this combination for meshes infected with S. aureus, S. epidermidis, and E. coli and the results showed that HApN inhibited both Gram-positive and Gram-negative bacteria growth, with the potential to prevent mesh-related infection [86]
Summary
Based on the combination of new generation technologies and cell-based therapies, the biocompatible and bioactive properties of medical products can lead to progress in repairing injured or harmed tissues and in tissue regeneration. The composition of the material and its structure can significantly affect the biocompatibility of the prosthetic device [5], but the mechanical resistance of wall reconstruction is reported to. The composition of the material and its structure can significantly affect the biocompatibility of the prosthetic device [5], but the mechanical resistance of wall reconstruction is reported to be similar, independently of the material used. The second generation of these medical devices proposes composite composite systems, combining various materials, and offers minimal adhesion formation. Associated infections, due to the post-operative complications that affect the patients’ quality quality of life anda have high socio-economic [16,17] Incontext, this context, the developof life and have high asocio-economic impactimpact.
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