Abstract
Denture-induced stomatitis is one form of candidiasis. It is characterised as inflammation and erythema of the oral mucosa underneath the denture-bearing areas and clinically classified into three types according to severity. Denture hygiene, appropriate mouth rinses and the use of antifungal therapy are commonly used to treat the condition, but new technologies are emerging that may assist in its treatment. The aim of this systematic review is to determine if silver nanoparticles inhibit the growth of Candida Albicans when included in acrylic dentures and in different denture liners. A protocol was developed and published on PROSPERO (Registration No: CRD42019145542) and with the institutional ethics committee (Registration No: BM20/4/1). The protocol includes all aspects of a systematic review namely: selection criteria, search strategy, selection methods using predetermined eligibility criteria, data collection, data extraction, critical appraisal of included studies, and the intended statistical analyses such as calculating risk ratios (RR) for dichotomous outcomes and presented at 95% confidence intervals, a meta-analysis, if possible or a narrative report as needed. With rigorous inclusion criteria set and databases identified for searching, appropriate clinical and laboratory studies may be obtained but the results and its interpretation and translation into clinical practice may be a challenge as these depend on the quality of the research.
Highlights
Denture-induced stomatitis is one form of candidiasis
The United Nations released the key findings of the World Population Prospects in 2019 and they estimate that life expectancy will increase to 77 years [2]
The preferred reporting system will follow the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines [18]. This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO): CRD42019145542 and with the University of the Western Cape (UWC) institutional ethics committee (Registration No: BM20/4/1)
Summary
Denture-induced stomatitis is one form of candidiasis. It is characterised as inflammation and erythema of the oral mucosa underneath the denture-bearing areas and clinically classified into three types according to severity. By 2030 older persons are expected to outnumber children under the age of 10 years. This increase in the elderly population means that more individuals may lose their teeth. In 2013, it was reported that edentulism accounted for a third of the burden of disease in low and middle income countries globally [3]. In low-income countries, the early loss of teeth due to extractions are common. The resulting loss of teeth influences speech, aesthetics, the ability to eat and socialise
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