Abstract
Introduction: the long term success of root canal treatment is ultimately related to the effective debridement and disinfection of the root canal system. Hence, the irrigants play an important role in achieving the good penetrability and bactericidal activity. The present study was mainly aimed at evaluating the invitro antimicrobial efficacy of Novel Ethanolic Extract of Morinda Citrifolia by agar well diffusion and minimal inhibitory concentration. Materials and Methods:the antimicrobial efficacy of the Novel Ethanolic Extract of Morinda Citrifolia was tested using agar well diffusion and minimal inhibitory concentration was assessed. The zone of inhibitions were determined at 10 mg/ml concentration of Ethanolic Extract of Morinda Citrifolia on agar well plate and Minimal Inhibitory Concentration (MIC) against tested microorganism. Results: results obtained in the present study by both qualitative and quantitative experiments revieled that the tested Ethanolic Extract of Morinda Citrifolia possesses potential antibacterial activity against Enterococcus Feacalis when compared with standard antibiotic tetracycline. the highest zone of inhibition of 15mm was showed at 1000micrograms by agar well diffusion assay. The optimal antimicrobial activity was seen at 250micrograms for Morinda Citrifolia against Enterococcus Feacalis.Conclusion: novel Ethanolic extract of Morinda Citrifolia has shown an optimal antimicrobial activity against E.Feaclais. But still, future studies are still needed.
Highlights
The long-term success of root canal treatment is related to the effective debridement and disinfection of the root canal system [1]
The present study was mainly aimed at evaluating the invitro antimicrobial efficacy of Novel Ethanolic Extract of Morinda Citrifolia by agar well diffusion and Broth dilution methods
The bacterial strains were grown in Mueller-Hinton agar (MHA) plates at 37°C the bacteria were grown in the nutrient broth at 37°C and maintained on nutrient agar slants at 4°C
Summary
The long-term success of root canal treatment is related to the effective debridement and disinfection of the root canal system [1]. Chemo-mechanical preparation plays a vital role in achieving successful endodontic therapeutic outcomes. Sodium hypochlorite (NaoCl) is one of the most commonly used root canal irrigant because of its ability to show a broad-spectrum antimicrobial activity and its ability to dissolve the necrotic pulp tissue [2]. Even though it is the most potent irrigant, it has some adverse characteristics like its tissue toxicity, allergic potential and disagreeable taste. This prompted for the search for alternative irrigants [3]
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