Abstract
Nigella sativa (kalonji) has been used since ancient times as a nutritional supplement and for treating various infections and chronic ailments. As pathogens become resistant to most drugs, kalonji can be used as an alternative compound in modern medicines. The use of herbal extracts as endodontic irrigants might be beneficial as a part of a growing trend to seek natural remedies for dental treatment.
 Aim: To compare the antibacterial potency of Aqueous Nigella sativa extract, Aqueous Neem leaf extract, and 3% Sodium Hypochlorite.
 Materials and Methods: Test solutions were tested against E. faecalis (ATCC 29212) to check for their Minimum Inhibitory Concentration (MIC) by double dilution method and Kill time to measure their antimicrobial potency to be used as an intracanal irrigant.
 Results: The study's limitations show that Aqueous Nigella sativa extract has a better antimicrobial effect than Aqueous Neem leaf extract and 3% Sodium Hypochlorite solution against E. faecalis.
Highlights
Elimination of microorganisms from the root canal is crucial to successful endodontic treatment
The study's limitations show that Aqueous Nigella sativa extract has a better antimicrobial effect than Aqueous Neem leaf extract and 3% Sodium Hypochlorite solution against E. faecalis
During the Minimum Inhibitory Concentration (MIC) investigation (Table 1) with Aqueous Nigella sativa extract, Aqueous Neem leaf extract, and 3% Sodium Hypochlorite solution, E. faecalis strains were sensitive to Aqueous Nigella sativa extract until the 4th dilution (12.5 μl/ml)
Summary
Elimination of microorganisms from the root canal is crucial to successful endodontic treatment. Instrumentation and irrigation promote significant microbial reduction during the stages of chemomechanical preparation. Complete eradication of intracanal infection is still unachievable by the methods currently available, and remaining microorganisms may cause reinfection of the root canal space. The most effective way to eliminate E. faecalis from the root canal space and dentinal tubule is by applying sodium hypochlorite or chlorhexidine in gel or liquid form. Due to the disadvantages of these two commonly used conventional irrigating solutions. The use of herbal alternatives has become the dernier cri due to increased antibiotic resistance against chemical medications. It is necessary to find a better alternative, which has led to the search for a herbal alternative
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