Abstract
Snail mucus is composed of bioactive compounds thought to have different biological properties for the treatment of some skin problems. Although Helix aspersa mucus is used in several cosmetic products, a detailed characterization of Eremina desertorum mucus composition and its biological activities is still missing. Mucus extracts (MEs) from H. aspersa and E. desertorum were prepared and tested for their antimicrobial and anti-inflammatory activities with their potencies in wound healing. Also, chemical characterization was performed by GC–MS analysis. Results showed that ME of E. desertorum gave higher inhibitory activity against resistant strains related to burn wound infections compared to ME of H. aspersa. Additionally, it revealed a significant anti-inflammatory activity. Moreover, we found that ME of E. desertorum lacked cytotoxicity and was able to significantly induce cell proliferation and migration through up-regulation of TGF-β1 and VEGF gene expression. Our results suggested that MEs of E. desertorum have higher biological effects than H. aspersa, which are attributable to antimicrobial, anti-inflammatory activities, cell proliferation and pave the way for further investigating its potential effect as a human therapeutic agent.
Highlights
Snail mucus is composed of bioactive compounds thought to have different biological properties for the treatment of some skin problems
The aim of the present study is the first to identify the mucus chemical composition of the desert snail E. desertorum compared to the garden snail H. aspersa under Egyptian conditions and explore it as a new antimicrobial, and anti-inflammatory approach against resistant pathogens of burn wound infections and its wound healing potency on human skin fibroblasts through the expression of some growth factor genes
The present study might be the first to investigate effect of Mucus extracts (MEs) of H. aspersa and E. desertorum against MDR or PDR pathogenic microorganisms isolated from burn wound infections
Summary
Snail mucus is composed of bioactive compounds thought to have different biological properties for the treatment of some skin problems. Mucus extracts (MEs) from H. aspersa and E. desertorum were prepared and tested for their antimicrobial and anti-inflammatory activities with their potencies in wound healing. Results showed that ME of E. desertorum gave higher inhibitory activity against resistant strains related to burn wound infections compared to ME of H. aspersa. Our results suggested that MEs of E. desertorum have higher biological effects than H. aspersa, which are attributable to antimicrobial, anti-inflammatory activities, cell proliferation and pave the way for further investigating its potential effect as a human therapeutic agent. The mechanism of anti-inflammatory agents depends on inhibiting the release of lysosomal constituents of activated neutrophils which can cause tissue damage and inflammation[20]
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