Antimicrobial effects of Ferula species- an herbal tactic for management of infectious diseases

Abstract

Drug resistance and new diseases are becoming serious threat for flora and animals. Scientists are developing more effective amalgams to thwart millions of demises. Traditional medication uses Ferula spp. in being conferred in this framework. We used Scientific direct, Google Scholar, PubMed, to research Ferula's antimicrobial profile amongst which we found five of Ferula spp. are antibacterial. Moreover, ferulenol from Ferula communis unveiled decent action. Four novel thiophene amalgams were attained from Ferula foetida roots (foetithiophenes C-F [3–6]). Foetithiophene F (6) showed toxicity to Gram-positive bacteria. Foetithiophene F from Ferula foetida has antibacterial and antifungal activities. Alkaloids, coumarins, flavonoids, saponins, opines, ergosterols, steroids, and terpenes overflow. Ferula spp. can be used for drug development after thorough follow-up investigations. Medicinal plant extracts cannot kill all pathogens. Chemicals can be extracted more effectively and selectively using plant-specific extraction approaches. Plant extracts' antimicrobial susceptibility is tested—capricious test discoveries. Ferula asafoetida L. is the keyderivation of Asafoetida, which has a pungent, persistent, and sulphurous odour and oleo-gum resin, which plays a vital protagonist in both medicine and nutrition. Asafoetida has been a spice and cure since ancient times. Recent study has shown relaxing, neuroprotective, memory-enhancing, digestive enzyme, antioxidant, antispasmodic, hypotensive, hepatoprotective, antibacterial, anticarcinogenic, anticancer, anticytotoxicity, anti-obesity, anthelmintic, and antagonistic properties. This paper discusses Asafoetida's pharmacology, therapy, and phytochemistry. Discovering novel antimicrobials from plant extracts is difficult despite efforts to improve antibacterial activity. Medicinal plant extracts must be researched for their mechanisms of action, chemical interactions, pharmacokinetics, and pharmacodynamics before being considered antibacterial. In this review, we explored Ferula spp.-based components' antimicrobial properties, processes, and chemical possibilities.