Abstract
Contamination of surgical, traumatic, and chronic wounds with microorganisms presents a challenge to successful wound healing. In the present in vitro study, a syntheticelectrospun fiber matrix (SEFM) cleared for use in the management of chronic, surgical, and traumatic wounds underwent USP (United States Pharmacopeia) <51> Antimicrobial Effectiveness Testing to determine its in vitro effectiveness against various microorganisms commonly found in non-healing wounds. The SEFM was tested in both sheet (s-SEFM) and micronized form (m-SEFM) againstEscherichia coli, Pseudomonas aeruginosa,Staphylococcus aureus,Aspergillus brasiliensis,Candida albicans,Proteus mirabilis, andEnterococcus faecalis. Testing was performed per the USP <51> standard on days 7, 14, and 28. Both the s-SEFM and m-SEFM met the USP <51> acceptance criteria for all microorganisms. The results obtained for s-SEFM demonstrated >1-log10reduction againstE. coli, S. aureus, P. aeruginosa, P. mirabilis, E. faecalis,andC. albicansat day 7; >3-log10reduction with no detection of these microbes at days 14 and 28, and no increase from initial inoculum at days 7, 14, and 28 againstA. brasiliensis.The results obtained for m-SEFM demonstrated >3-log10reduction with no detectable microorganisms at day 7. The results observed in this study indicate that the SEFM is effective in vitro at inhibiting bacterial and fungalgrowth and colonization per USP <51> testing.
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