Abstract
Background: Twenty three genera and twenty three species of the Lamiaceae family are native to Yemen. The greatest antibacterial efficacy against a wide range of pathogens, including Candida albicans, Staphylococcus aureus, Aspergillus fumigatus, and Escherichia coli was demonstrated by Lamiaceae essential oils. The primary components of Lamiaceae essential oils, including as carvacrol, thymol, p-cymene, 1,8-cineole, and caryophyllene, may be responsible for these characteristics. Method: The plant green branches and new leaves were sliced into little bits. A Clevenger-style all-glass equipment was used to hydro distills the essential oil for five hours in order to separate it from each component. After being moved to a glass vial with a screw top, each oil was dried (with Na2SO4) and kept at 4°C in the dark until analysis. For assessing antibiotic sensitivity, a variety of bacterial and fungal strains kept in stock culture at the Al-Mamoun laboratories center were utilized, including: Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Klebsiella pneumonia, Escherichia coli) and Fungi Candida albicans. In dichloromethane (DCM), the essential oil that had been previously synthesized was diluted 1/5, 1/3, and 1/ 1 v/v. Result: The plant has significant effect on Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and, Candida albicans. In addition, the extract has high effect on Candida albicans than on bacteria. And their more effect on Klebsiella pneumoniae than Escherichia coli. Conclusions: Result showed the plant has significant effect on staph. Aureus, E coli, Klebsielle, Candida albicans. The extract has high effect on Candida albicans than bacteria. Also the extract has high effect on Klebsiella than E. coli. The oil extract has more effect on gram negative than gram positive. Peer Review History: Received 21 March 2024; Revised 3 May 2024; Accepted 25 June; Available online 15 July 2024 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Jucimary Vieira dos Santos, Hemonorte Dalton Barbosa Cunha, Brazil, jucimaryvieira@yahoo.com.br Dr. Kamal Elbssir Mohammed Ali, Hail University KSA, kamalelbssir999@gmail.com
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