Abstract

A new national antimicrobial resistance surveillance program in Singapore public hospitals that uses WHONET detected high levels of methicillin resistance among Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. (49.6%), and third-generation cephalosporin resistance among Klebsiella pneumoniae (35.9%) hospital isolates in 2006. Antimicrobial drug resistance is a major problem in Singapore.

Highlights

  • A new national antimicrobial resistance surveillance program in Singapore public hospitals that uses WHONET detected high levels of methicillin resistance among Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. (49.6%), and third-generation cephalosporin resistance among Klebsiella pneumoniae (35.9%) hospital isolates in 2006

  • In 2001, the World Health Organization (WHO) launched the first global strategy to counter this phenomenon [3], a key component of which is the development of surveillance programs to monitor trends in antimicrobial drug resistance and use [3]

  • For a small city-state, comprehensive national surveillance is relatively easier for Singapore than for larger countries. Such surveillance of clinical microbiology isolates is a critical first step toward controlling the growing worldwide threat of antimicrobial drug resistance, and WHONET is a useful tool in this respect

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Summary

Antimicrobial Drug Resistance in Singapore Hospitals

Li-Yang Hsu,*1 Thean-Yen Tan,†1 Roland Jureen,‡ Tse-Hsien Koh,§ Prabha Krishnan,¶. A new national antimicrobial resistance surveillance program in Singapore public hospitals that uses WHONET detected high levels of methicillin resistance among Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. (49.6%), and third-generation cephalosporin resistance among Klebsiella pneumoniae (35.9%) hospital isolates in 2006. A new national antimicrobial resistance surveillance program in Singapore public hospitals that uses WHONET detected high levels of methicillin resistance among Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. Overarching surveillance programs monitoring antimicrobial drug–resistance trends on a national or regional level are present in Australia [4] and Europe [5]. Such is not the case in Singapore, where surveillance efforts have generally been conducted only at the institutional level, with limited sharing and analysis of data. Drug-resistant clinical bacterial isolates cultured at public sector hospitals, Singapore, 2006*

Resistant ICU isolates
Findings
Conclusions

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