Antimicrobial, antioxidant, anticancer activities of Syzygium caryophyllatum (L.) Alston

Abstract

Background: Syzygium caryophyllatum (L.) Alston is an endangered tree species belonging to the Myrtaceae family. Objective: To evaluate the antimicrobial, antioxidant and anticancer activities of the leaf extract. Materials and Methods: Disc diffusion method was used for antimicrobial screening of four bacterial and three fungal strains. Scavenging ability of the extract was determined using 2,2‑diphenyl‑1‑picrylhydrazyl assay. Hep2 cell line was used to evaluate the cytotoxicity by 3‑(4, 5‑dimethyl thiazol‑2yl)‑2, 5‑diphenyl tetrazolium bromide assay. Results: The zone of inhibition was high for the extract against all the selected strains used. Antioxidant potential was more at higher concentration (400 µg/ml). The extract showed maximum Hep2cell inhibition at higher concentration (9.80% cell viability in 1000 µg/ml). Conclusions: Antioxidant, antimicrobial and anticancer studies using leaves of Syzygium caryophyllatum showed that it has potential utilization in pharmaceutical industry. Key words: Anticancer, antimicrobial, antioxidant, myrtaceae, Syzygium caryophyllatum