Abstract
In this experiment, biosynthesized silver nanoparticles (AgNPs) were synthesized using aqueous leaf extract of Erythrina suberosa (Roxb.). The biosynthesis of silver nanoparticle was continuously followed by UV-vis spectrophotometric analysis. The response of the phytoconstituents resides in E. suberusa during synthesis of stable AgNPs were analyzed by ATR- fourier-transform infrared spectroscopy. Further, the size, charge, and polydispersity nature of AgNPs were studied using dynamic light scattering spectroscopy. The morphology of the nanoparticles was determined by scanning electron microscopy. Current result shows core involvement of plant extracts containing glycosides, flavonoids, and phenolic compounds played a crucial role in the biosynthesis of AgNPs. The antimicrobial activities of silver nanoparticles were evaluated against different pathogenic bacterium and fungi. The antioxidant property was studied by radical scavenging (DPPH) assay and cytotoxic activity was evaluated against A-431 osteosarcoma cell line by MTT assay. The characteristics of the synthesized silver nanoparticles suggest their application as a potential antimicrobial and anticancer agent.
Highlights
Silver nanoparticles are widely used in pharmaceutical industry in the fabrication of ointments and creams to inhibit burns and wounds related infections (Satyavani et al, 2011)
Current investigation result of antioxidant potential of E. suberosa offers an affirmative report toward hypothetical mechanism about involvement of antioxidant molecules from the leaf extract in the biogenic synthesis of silver nanoparticles
This study strongly revealed the significant antiproliferative activity of biosynthesized silver nanoparticles
Summary
Silver nanoparticles are widely used in pharmaceutical industry in the fabrication of ointments and creams to inhibit burns and wounds related infections (Satyavani et al, 2011). Silver nanoparticles can be synthesized using a variety of chemicals and physical methods, involving chemical reduction (Vorobyova et al, 1999; Tan et al, 2002; Yu, 2007), photochemical reduction (Kéki et al, 2000; Pileni, 2000; Sun et al, 2001; Mallick et al, 2005), electrochemical reduction (Sandmann et al, 2000; Liu and Lin, 2004), and heat vaporization (Bae et al, 2002; Smetana et al, 2005) These processes involve several toxic chemicals as reducing agents. Because of using noble metal nanoparticles in areas of human contact (Song and Kim, 2008), there is an emergent need to develop ecofriendly biosynthesis processes that hinders the use of toxic chemicals
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