Abstract
Murraya paniculata (MP) can be used as a reducing agent to produce silver nanoparticles (AgNPs) using a simple procedure. AgNPs are characterized in morphological and chemical properties, antioxidant activity, and cytotoxicity. The morphology of AgNPs derived from MP shows a face-centered cubic structure, spherical shape with an average particle size of 23 nm. The chemical structure shows characteristic peaks of AgNPs using UV-vis spectrometer at 438 nm. The formation of AgNPs is confirmed by analyzing their vibrational states under infrared radiation; typical peaks of AgNPs are recognized: at 3429 cm−1 (O-H stretch, H-bonded alcohols, phenols groups), 2923 cm−1 (C-H stretch alkanes), 1626 cm−1 (N-H bend 1° amines), 1583 cm−1 (C-C stretch in ring aromatic), 1039 cm−1 (C-N stretch aliphatic amines), 728 cm−1 (C-Cl stretch alkyl halides), and 589 cm−1 (C-Br stretch alkyl halides), respectively. AgNPs produced from MP show antioxidant activity and cytotoxicity. They show the highest sensitivity toward Bacillus cereus. Cytotoxicity of biosynthesized AgNPs, determined by scratch wound assay on in vitro human endothelial vein cell, created from MP showed dose-dependent activity. These AgNPs, at a concentration of 15.625 μg/mL, stimulate the proliferation and migration of endothelial cells (EC) showing an angiogenic activity.
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