Abstract
Development of antibacterial and antibiofilm surfaces is in high demand. In this study, nanocomposite of Poly (ε-caprolactone)/Cloisite 30B was prepared by the solvent casting method. The membranes were characterised by SEM, AFM, and FTIR. Evaluation of water uptake, antimicrobial, antibiofilm, and microbial barrier properties demonstrated a significant antimicrobial and antibiofilm activity against MTCC strain of Staphylococcus haemolyticus and strong biofilm positive Staphylococcus epidermidis of clinical origin at low clay concentrations. These membranes acted as an excellent barrier to the penetration of microorganism. These nanocomposites can have promising applications in various fields including packaging.
Highlights
The development of antibiotic resistance in microbes (Neu 1992; Stewart and Costerton 2001) has turned into a major issue in the healthcare sector
The light colored clumps on the membrane surfaces of PCC3 and PCC5 showed the presence of clay particles (Fig. 1)
From the Atomic force microscopy (AFM) images, nanoscale roughness of the membranes surfaces was measured as Ra and dense uniaxially oriented fibrils of PCL were observed in PCC0 as its characteristic feature (Cheng and Teoh 2004; Ng et al 2000)
Summary
The development of antibiotic resistance in microbes (Neu 1992; Stewart and Costerton 2001) has turned into a major issue in the healthcare sector. As microorganisms are developing resistance to all the major antibiotics, there is an increased demand for the development of alternative methods for resisting microbial infections (Chatterjee et al 2016). Nanostructured materials have gained a lot of popularity in biomedical applications due to their broad antibacterial, antimycotic, and antiparasitic activities. Major attractions with the use of nanomaterials include their size and surface area-based enhanced activity, easy penetration into the cells, and most remarkably their multitargeted action. Performance of various materials used for biomedical applications has significantly been improved by the addition of nanoparticles. Exploration of antimicrobial properties of various nanomaterials is significantly important to generate cost-effective, biodegradable, and non-toxic anti-infective surfaces. As the very basic step that determines the survival and growth of microorganisms is its attachment to surface, prevention of this step can have significant medical and industrial applications
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