Abstract
A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product.
Highlights
Development and application of many interesting wound dressing variants based on natural polymers was described in numerous scientific and patent reports of recent years [1]
As bacterial cellulose (BC) was soaked in the cell suspension during the “adsorption” step, it became inflatable and the bacteria were adsorbed onto the BC surface due to its porous structure and properties In the incubation step, the immobilized cells' growth was supported by the nutritional compounds that diffused into BC's space
The current study provides firm evidence supporting the fact that probiotic Bacillus subtilis (BS) P-2 have positive effect on cutaneous wound healing too
Summary
Development and application of many interesting wound dressing variants based on natural polymers was described in numerous scientific and patent reports of recent years [1]. A promising research direction is design of wound coatings based on the bacterial cellulose (BC) synthesized by Gluconoacetobacter xylinus [2, 3] Such materials are biocompatible, i.e. not toxic, do not cause allergies and physical rejection [4]. The Biofills product was used for several skin injury treatments such as basal cell carcinoma/skin graft, severe body burns, facial peeling, sutures, dermabrasions, skin lesions, chronic ulcers, and both donor and receptor sites in skin grafts [10] Another product called Xcell has an ability to simultaneously donate and absorb moisture from the wound, conforming to wounded and intact skin differently [11]
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