Abstract
“San Huang Powder,” a nonsterile milled herb powder, is frequently used to treat burn wounds in traditional Chinese herbal medicine. However, treating a wound with a nonsterile dressing or reagent is not compatible with the current guidelines in modern medicine. Therefore, we investigated the bactericidal and anti-inflammatory activities of four herb extracts used in “San Huang Powder” in vitro. Meanwhile, an in vivo porcine model with superficial second-degree burns was used for the experiments since the size and skin composition of pigs are the closest to that of the human body. The minimal bactericidal concentration (MBC) of the herb extracts was determined. The in vitro assay indicated that Rhubarb and Phellodendron bark extracts decreased the levels of inflammatory cytokines, IL-8, and GM-CSF on LPS-induced HMEC-1 cells. In accordance with this result, the histopathological evaluation results showed that the efficacy of “San Huang Powder” containing both herb materials was much better than the group without Rhubarb. Our results not only provide a basis to understand why “San Huang Powder” has been used to clinically treat wounds without sterilization directly since ancient times but also show the advantages of using multiple herb materials simultaneously on wound sites to prevent infection during treatment. Rhubarb is the recommended ingredient involved in the preparation of “San Huang Powder” to ensure the healing efficacy of burn wounds.
Highlights
“San Huang Powder” is a widely used traditional Chinese herbal medicine. e name of this preparation was first mentioned in an ancient medical book, Beiji Qianjin Yao Fang, published in 652 B.C
Evidence-Based Complementary and Alternative Medicine in healing burn wounds to examine the efficacy of two different “San Huang Powder” recipes. e results obtained in this study provide the scientific basis for its clinical use and insight for preparation of generation “San Huang Powder” extract
One of the main problems associated with herbal medicine is the high batch-to-batch variability regarding the concentrations of its active components. e content of pure chemical reference standards in herbal products is used as an indicator for quality control and standardization
Summary
“San Huang Powder” is a widely used traditional Chinese herbal medicine. e name of this preparation was first mentioned in an ancient medical book, Beiji Qianjin Yao Fang, published in 652 B.C. E name of this preparation was first mentioned in an ancient medical book, Beiji Qianjin Yao Fang, published in 652 B.C. It is well known for the treatment of first- and second-degree burn wounds [1,2,3]. The recipes of “San Huang Powder” vary in different ancient medical books. There is no systematic study comparing the efficacy of different “San Huang Powder” recipes for the treatment of burn wounds to date. E milled herbal powder without sterilization is used to treat wounds directly in folk medicine. Evidence-Based Complementary and Alternative Medicine in healing burn wounds to examine the efficacy of two different “San Huang Powder” recipes. Evidence-Based Complementary and Alternative Medicine in healing burn wounds to examine the efficacy of two different “San Huang Powder” recipes. e results obtained in this study provide the scientific basis for its clinical use and insight for preparation of generation “San Huang Powder” extract
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