Abstract
Nystatin is a tetraene diene polyene antibiotic showing a broad spectrum of antifungal activity. In the present study, we prepared a nystatin nanocomposite (Nyst-CS-MNP) by loading nystatin (Nyst) on chitosan (CS) coated magnetic nanoparticles (MNPs). The magnetic nanocomposites were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetry analysis (TGA), vibrating sample magnetometer (VSM), and scanning electron microscopy (SEM). The XRD results showed that the MNPs and nanocomposite are pure magnetite. The FTIR analysis confirmed the binding of CS on the surface of the MNPs and also the loading of Nyst in the nanocomposite. The Nyst drug loading was estimated using UV-Vis instrumentation and showing a 14.9% loading in the nanocomposite. The TEM size image of the MNPs, CS-MNP, and Nyst-CS-MNP was 13, 11, and 8 nm, respectively. The release profile of the Nyst drug from the nanocomposite followed a pseudo-second-order kinetic model. The antimicrobial activity of the as-synthesized Nyst and Nyst-CS-MNP nanocomposite was evaluated using an agar diffusion method and showed enhanced antifungal activity against Candida albicans. In this manner, this study introduces a novel nanocomposite that can decrease fungus activity on-demand for numerous medical applications.
Highlights
Advances in nanobiotechnology have led to the preparation of iron oxide nanoparticles with specific sizes and shapes which have the potential to be used as new antimicrobial agents [1,2,3]
The peak intensity of the NystCS-magnetic nanoparticles (MNPs) nanocomposite is lower than that of the CS-coated MNPs and MNPs which may due to the fact that the MNPs are incorporated with Nyst drugs
A Nyst-CS-MNP nanocomposite was successfully prepared by coating MNPs nanoparticles with CS and loading with the Nyst drug
Summary
Advances in nanobiotechnology have led to the preparation of iron oxide nanoparticles with specific sizes and shapes which have the potential to be used as new antimicrobial agents [1,2,3]. The functional activities of iron oxide nanoparticles are influenced largely by their size. Iron oxide nanoparticles have numerous applications in medicine due to their magnetic, physical, chemical, and effective biological properties. Nanoparticles with smaller particle sizes have been shown to possess antimicrobial properties [4]. The antimicrobial activity of iron oxide nanoparticles has largely been studied against different organisms [1, 5,6,7] and has been shown to depend on three factors: size, stability, and concentration in the growth medium. Due to the smaller size of nanoparticles
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