Abstract
AbstractThe presented study explores the anticancer potency of a novel series of chalcone clubbed 2,4‐dimethyl‐1H‐pyrrole‐3‐carboxamide derivatives. In vitro antimicrobial screening concluded that five compounds are potential against Candida albicans having inhibition of growth in the range of 46.38%–73.05% against at the concentration of 32 μg/mL. The antiproliferative screening against 60 cancer cell lines revealed that seven compounds have great potential against the various types of cancer cell lines with inhibition of growth in the range of 41%–71%. The structure–activity relationship study concluded that the hydrazide bond is more significant than the carboxamide bond. In silico study of highly potential derivatives obeys each parameter of Lipinski rule of five and qualified drug‐likeness behavior. The presented pyrrole‐chalcone template delivered various candidates as anticancer agents, and those could be a potential scaffold to develop the new anticancer drug.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
