Antimicrobial and antioxidant studies of Schiff base, 2-(2-hydroxy-2-methyl-1-phenylpropylidene) hydrazine carbothioamide and its mixed ligand cd (II) complexes

Abstract

New mononuclear mixed ligand Cadmium(II) complexes of the type [Cd(L)(diimine)] (1,2) [where L = 2-(2-hydroxy-2-methyl-1-phenylpropylidene)hydrazinecarbothioamide; diimine = 2,2’-bipyridine (1), 1,10-phenanthroline (2)] have been synthesized and characterized by spectroscopic techniques such as FT-IR, UV-Visible, and1H and 13CNMR Spectroscopy. From the investigations of spectral data, it is evident that the heterocyclic bases (2,2’-bipyridine and 1,10-Phenanthroline) act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms addition to azomethane nitrogen, thiolate Sulphur, and hydroxyl oxygen in the Schiff base ligand. The synthesized Schiff base metal chelates have been screened for their anti-microbial activities using the agar well diffusion method against different selected types of bacteria and fungi in addition to antioxidant activity. The prepared Schiff base ligand and its metal complexes exhibited good antimicrobial and antioxidant activities. The antibacterial and antifungal efficacy of Complex-1 was higher than that of all the prepared compounds. In the case of antioxidant activity, Complex-2 has stronger scavenging activity among them. Keywords: Cd (II) metal complexes, 2,2’-Bipyridine, 1,10-Phenanthroline, Antimicrobial activities.