Abstract
A new series of aurones 3a–x has been synthesized by aldol condensation of N-(Un)substituted quinolone-3-carbaldehydes 1a–h and (Un)substituted benzofuran-3(2H)-ones 2a–c in the presence of 10mol% NaOH in ethanol using a microwave irradiation method. All the aurone derivatives were screened for in vitro antimicrobial activity against a representative panel of bacterial and fungal pathogens using a broth microdilution method. The majority of the synthesized compounds elicited more or equipotent inhibitory action against all the tested bacterial and fungal strains. In vitro antioxidant activity was evaluated by the Ferric Reducing Antioxidant Power (FRAP) method. Compounds 3k and 3u displayed the highest antioxidant potential.
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