Abstract
3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML2Cl2], while the Cr(III) complex has the formula [CrL2Cl2]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.
Highlights
Drug resistance has become a growing problem in the treatment of infectious diseases caused by bacteria and fungi [1]
3-Aminocoumarin (Figure 1) is the key intermediate for the metal complexes synthesized in this work
The complexes were synthesized by the reactions of 3-aminocoumarin with the metal ions, in which the ligand behaves as a bidentate ligand through its oxygen and nitrogen atoms
Summary
Drug resistance has become a growing problem in the treatment of infectious diseases caused by bacteria and fungi [1]. Coumarin derivatives exhibit excellent biological and medical activities [22], and have the superior thermal stability and outstanding optical properties, including extended spectral responses, high quantum yields, and superior photostability. Optical applications of these compounds, such as laser dyes, nonlinear optical chromophore, fluorescent whiteners, fluorescent probes, polymer science, optical recording and solar energy collectors, have been widely investigated [23,24,25,26,27,28]. The microbial activities of all synthesized compounds and their in vitro antioxidant activities were investigated
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