Abstract
A precipitation method is used to synthesise calcium doped zinc oxide (CaZnO) nanocomposites (NCs). Xray diffraction (XRD) analysis validated the hexagonal wurtzite structure of the synthesised CaZnO NCs. Transmission electron microscopy (TEM) images illustrate that the fabricated CaZnO NCs are spherical in shape. Energy dispersive X-ray (EDAX) spectroscopy is used to determine the elemental composition. The Fourier transform infrared (FTIR) spectrum of CaZnO NCs exhibited a peak of Zn-O vibration at 434 cm-1. Violet, blue and green emission peaks are noticed for CaZnO NCs in the photoluminescence (PL) spectra. The ZnO, CaO, CaZnO NCs are assessed using the well diffusion method for antimicrobial efficacy against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and Candida albicans (C. albicans). In comparison to ZnO and CaO nanomaterials (NMs), CaZnO NCs showed highest antimicrobial activity. MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetra zolium bromide) assay is used to ascertain cytotoxicity against human breast cancer cell line (MDA-MB-231). CaZnO NCs reduce cell viability as their concentration increases which emphasise their potent anticancer activity against MDA-MB-237 cells.
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