Abstract
More than 65% of all human bacterial infection are associated with biofilm. Bacteria in such biofilms are 10 to 1000-fold more resistant to antibiotics than free living bacteria cells. Organisms such as S. aureus and P. aeruginosa are responsible for a significant number of biofilm related infections. In this study, we investigated the antimicrobial and anti-biofilm activity of C. longa L. rhizome extract against biofilm producing S. aureus and P. aeruginosa isolates. The results of MIC and MBC demonstrated promising antibacterial activity of the rhizome extract. TLC and column chromatography detected various curcuminoids while phytochemical analysis also reveals presence of number of bioactive compounds such as alkaloids, flavonoids, phenolics, terpenoids, etc. Micro titer plate assay indicated significant inhibition of biofilm formation in clinical isolates treated with turmeric extract. Thus, on basis of our results turmeric extracts can be considered as natural antibiofilm and antibacterial agent.
Highlights
Turmeric is a spice derived from the rhizomes of Curcuma longa L., belonging to ginger family (Zingiberaceae) [1]
We investigated the antimicrobial and anti-biofilm activity of C. longa L. rhizome extract against biofilm producing S. aureus and P. aeruginosa isolates
The aim of this study was to investigate the antibiofilm activity of Antimicrobial and antibiofilm potential of Curcuma longa Linn. rhizome extract against biofilm producing S. aureus and P. aeruginosa isolates
Summary
Turmeric is a spice derived from the rhizomes of Curcuma longa L., belonging to ginger family (Zingiberaceae) [1]. Turmeric is extensively explained as a medicinal plant in Indian material medica (Dravyaguna Sastra) and has been well documented in Ayurveda for its therapeutic potentials and described in Kusthagna (Anti-dermatosis) and Visaghna (Anti-poisonous) [3]. Ayurvedic medicine documents it as a treatment for various respiratory conditions such as asthma, bronchial hyperactivity and allergy, as well as for liver disorders, anorexia, rheumatism, diabetic wounds, runny nose, cough and sinusitis [4]. The dried rhizome of turmeric contains a large number of medicinally important phytochemicals known as the curcuminoids [6] This polyphenolic compound has shown wide variety of biological activities from antioxidant, neuroprotective, antitumor, anti-inflammatory, antiacidogenic, radioprotective to arthritis[7]. Demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), Curcumin is the best studied active ingredient of turmeric and has been assessed in various clinical trials its therapeutic ability on inflammatory, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders [8, 9]
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