Antimicrobial and Anti-quorum Sensing Activity of Geranium sp.

Abstract

Aim: Antibiotic resistance, which has increased rapidly in recent years, is one of the leading public health threats. Alternative methods are being investigated for effective antibiotics in the fight against resistance. Geranium species are widely used for constipation, digestive disorders, and diabetes. It is also known that the plant is used in various public health applications. In line with this information, it was aimed to investigate the antimicrobial and anti-quorum sensing properties of the Geranium sp. Material and Methods: In this study it was aimed to prepare methanol, ethyl acetate, ethanol, and hexane extracts of Geranium sp. flower parts belonging to Rize province and investigate their antimicrobial activities by agar well diffusion method against various Gram-negative and Gram-positive bacteria and two fungal species. Anti-quorum sensing activity was determined using Chromobacterium violaceum strain. Results: Methanol extract of Geranium sp. showed antimicrobial activity against seven species whereas extraction with ethyl acetate showed antimicrobial activity against eight species. The ethanol extracted samples have the lowest antimicrobial activity so that only six species were affected. Additionally, methanol extract of Geranium sp. had violacein inhibition activity. Conclusions: As a result, it was determined that the plant, especially its methanol extract, has antimicrobial and anti-quorum sensing properties.