Abstract
Multidrug-resistant bacteria (MDR) are becoming a global health problem, and scientists are continuously investigating new strategies to fight against MDR. Seaweeds are an important source of biological compounds and can serve as natural sources for bacterial infection control. This study evaluated the antimicrobial and anti-quorum sensing (QS) activities of phlorotannins from Hizikia fusiforme. The phlorotannins exhibited antimicrobial activity against selected bacterial pathogens and inhibited QS activity of the reporter strain Chromobacterium violaceum 12472 by inhibiting purple pigment production. Phlorotannins can decrease the bacterial motility, reduce the production of extracellular protease, hemolysin, and pyocyanin and inhibit biofilm formation of Pseudomonas aeruginosa. In vivo studies showed that phlorotannins can reduce P. aeruginosa inflicted mortality in Caenorhabditis elegans. This study shows that phlorotannins from H. fusiforme have certain antimicrobial and anti-quorum sensing activities and have the potential to control bacterial infection for pharmaceutical usage.
Highlights
Antibiotics have been used for bacterial infection treatment for decades, with the majority used as feed additives for animal husbandry (Van Boeckel et al, 2017)
We investigated the effects of phlorotannins from brown seaweed (Hizikia fusiforme) on quorum sensing (QS) activity in Chromobacterium violaceum and virulence factors and biofilm formation in Pseudomonas aeruginosa
Virulence factors are required as a critical condition for bacterial infection
Summary
Antibiotics have been used for bacterial infection treatment for decades, with the majority used as feed additives for animal husbandry (Van Boeckel et al, 2017). The emergence and spread of multidrugresistant bacteria (MDR) have potentially profound consequences for public health in low- and middle-income countries (Van Boeckel et al, 2019). Quorum sensing (QS) is a cell-to-cell communication pathway in microorganisms, in which the expression of several genes, often associated with virulence factors and biofilm formation, is controlled via the production and detection of signal molecules in a population density-dependent manner (Rutherford and Bassler, 2012). Signal disruption referred to as quorum quenching has been described in several biological systems and is being explored as a novel approach to fight bacterial infections. Disruption of QS is a competition strategy used by microorganisms and higher organisms (Defoirdt, 2018; Fleitas Martıń ez et al, 2019)
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