Abstract
Wound infection is a serious clinical problem, and the most common infection-causing bacteria are Staphylococcus aureus and Pseudomonas aeruginosa. Angelica dahurica and Rheum officinale extract (ARE) was reported to accelerate excisional wound healing in rats. In this study, we investigated the therapeutic effects of ARE on bacterial-infected wounds. Thirty Sprague-Dawley rats were divided into three groups: normal saline (NS), ARE, and biomycin ointment (BO). Full-thickness dorsal excisions in all the rats were infected with 108 colony-forming units of S. aureus; the treatments were applied once daily for 7 days. Results showed that the residual wound area in ARE group was smaller than those in NS and BO groups. TBCs on wound sites gradually decreased in ARE and BO groups. The body temperature and plasma inflammatory cytokines (TNF-α, IL-6) levels increased after bacterial infection at 24 h in all groups. After treatment, BT and inflammatory cytokines levels decreased in ARE group. Histological observations showed ARE group exhibited earlier scab formation, denser dermal granulation tissue, thicker epidermis, and more angiogenesis markers than the other groups. In conclusion, ARE accelerated wound healing in S. aureus-infected wounds. We proposed ARE exhibited potential antimicrobial and anti-inflammatory effects and stimulated angiogenesis, thus improving healing in infected wounds.
Highlights
Wound infection is a serious clinical problem, and the most common infection-causing bacteria are Staphylococcus aureus and Pseudomonas aeruginosa
The wound healing results showed that the residual wound area in the ARE group was smaller than that in the biomycin ointment (BO) group on days 1, 3, 5, 7, 10, and 14 after treatment (Fig. 2)
The Total bacterial counts (TBCs) on wound sites gradually decreased in the ARE and BO groups after treatment
Summary
Wound infection is a serious clinical problem, and the most common infection-causing bacteria are Staphylococcus aureus and Pseudomonas aeruginosa. Angelica dahurica and Rheum officinale extract (ARE) was reported to accelerate excisional wound healing in rats. We proposed ARE exhibited potential antimicrobial and anti-inflammatory effects and stimulated angiogenesis, improving healing in infected wounds. Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacterial pathogens found in infected wounds[4,5]. Studies have shown that TCM treatments may provide multiple benefits, including anti-inflammatory, antimicrobial, and cell-stimulatory activities, which collectively promote wound healing[14,15]. A previous study reported the antimicrobial and anti-inflammatory effects of Angelica dahurica and Rheum officinale extract (ARE) and its ability to accelerate wound healing in excisional wounds in rats[15]. In the present study, an excisional wound rat model was used to investigate the effects of ARE on infected wound
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