Abstract
With the evolution of bacterial resistance over conventional antimicrobials and the development of new antimicrobials, the search for new compounds of natural origin has intensified, since plants with therapeutic potential constitute a source of new biologically active compounds, encouraging the development of new therapeutic options. The objective of this study was to evaluate the antibacterial and anti-adherent activity of the ethanolic extract of Praxelis clematidea (Griseb.) R.M. King & Robinson (Asteraceae) on strains of Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae, Pseudomonas aeruginosa and Enterococcus faecalis. Tests were carried out to determine the MIC and MBC by means of broth microdilution in 96-well plates, and to determine the MICA, a technique with inclined tubes in the presence of 5% sucrose was used. It was observed that the ethanolic extract of P. clematidea has strong bactericidal activity on K. pneumoniae, and moderate bactericidal activity on S. pneumoniae and E. faecalis. Being able to inhibit adherence to K. pneumoniae strains. Thus, the ethanolic extract of P. clematidea proves to be effective as an antimicrobial in the control and prevention of infections by S. pneumoniae, K. pneumoniae and E. faecalis. It also has an effective anti-adherent effect on K. pneumoniae strains.
Highlights
It was observed that the ethanolic extract of P. clematidea has strong bactericidal activity on K. pneumoniae, and moderate bactericidal activity on S. pneumoniae and E. faecalis
Due to the significant relationship between these microorganisms and the alteration of the oral microbiota associated with systemic pathologies, the current evolution of bacterial resistance and the search for new microbial agents, especially of natural origin, the objective of this study is concentrated on the antimicrobial evaluation of the extract P. clematidea on strains of Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae, Pseudomonas aeruginosa and Enterococcus faecalis
Observing that the ethanolic extract was able to inhibit the growth of K. pneumoniae at a concentration of 512 μg/mL, S
Summary
Given the relevance of maintaining oral health in the prevention of systemic pathologies of high social impact (Asai et al, 2015), it is observed with high and varied frequency different microorganisms exogenous to the oral cavity Among these microorganisms, stands out the Staphylococcus aureus, considered the dominant oral pathogen in ICU patients and in chronic elderly patients (Ortega et al, 2015), Streptococcus pneumoniae, identified as the most prevalent etiologic agent in infections associated with oral microbiota alteration (Awano et al, 2008; Kadioglu, Weiser, Paton & Andrew, 2008), Klebsiella pneumoniae, with a high prevalence in the oral cavity of stroke patients (Lam, McMillan, Samaranayake, Li & McGrath, 2013; Malik et al, 2018), the presence of Pseudomonas aeruginosa in the oral microbiota has been associated with the development of respiratory infections in hospitalized and immunosuppressed patients (Persson et al, 2008; Raghavendran, Mylotte & Scannapieco, 2007), and Enterococcus faecalis had its Research, Society and Development, v. Due to the significant relationship between these microorganisms and the alteration of the oral microbiota associated with systemic pathologies, the current evolution of bacterial resistance and the search for new microbial agents, especially of natural origin, the objective of this study is concentrated on the antimicrobial evaluation of the extract P. clematidea on strains of Staphylococcus aureus, Streptococcus pneumoniae, Klebsiella pneumoniae, Pseudomonas aeruginosa and Enterococcus faecalis
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