Abstract
Chemical investigation on the crude base of the Pandanus amaryllifolius leaves led to the isolation and identification of pandamarilactone-1 (1), pandamarilactone-32 (2), pandamarilactonine-A (3), and pandamarilactonine-B (4). Their structures were elucidated based on 1H and 13C NMR and in comparison with the literature data. Compound 3 was found to be the most active among the four isolates with an MIC of 15.6 ug/mL and MBC of 31.25 ug/mL against Pseudomonas aeruginosa. This is the first report on the antimicrobial activity of the isolated alkaloids from the genus Pandanus.
Highlights
The family Pandanaceae or the screw pine family is composed of four monocotyledon genus: the Pandanus, Freycinetia, Sararanga, and Martellindendron (Callmander, 2001; Callmander et al, 2003)
Chemical investigation on the crude base of the Pandanus amaryllifolius leaves led to the isolation and identification of pandamarilactone-1 (1), pandamarilactone-32 (2), pandamarilactonine-A (3), and pandamarilactonine-B (4)
Chromatographic purification of the crude base of P. amaryllifolius leaves led to the identification of pandamarilactone-1 (1) (Nonato et al, 1993), pandmarilactone-32 (2) (Nonato et al, 1993), pandamarilactonine-A (3) (Takayama 2002), and pandamarilactonine-B (4) (Takayama 2002) (Fig. 1)
Summary
The family Pandanaceae or the screw pine family is composed of four monocotyledon genus: the Pandanus, Freycinetia, Sararanga, and Martellindendron (Callmander, 2001; Callmander et al, 2003). The largest among the four, the genus Pandanus of about 700 species, is prevalent in tropical and sub-tropical areas, especially on the Pacific islands, Malaysian islands and Australia. The P. amaryllifolius commonly known as the fragrant screw pine because of its scented leaf is used to refresh the body, reduce fever, and relieve indigestion. Phytochemical analysis on the leaves and roots of P. amaryllifolius had elaborated mostly the presence of alkaloids (Tan et al, 2010a; Tan et al, 2010b). There is a dearth on the pharmacological activity on the identified alkaloids.
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