Abstract
Phytochemical investigations of the endophytic fungus of an unidentified Ascomycete, isolated from Meliotus dentatus led to the isolation of two new polyketide metabolites named cis-4-acetoxyoxymellein and 8-deoxy-6-hydroxy-cis-4-acetoxyoxymellein. The structures of the two new polyketides were confirmed on the basis of 1D and 2D NMR techniques. Preliminary studies showed that both of the new polyketides displayed strong antibacterial activity towards Escherichia coli and Bacillus megaterium. cis-4-Acetoxyoxymellein and 8-deoxy-6-hydroxy-cis-4-acetoxyoxymellein also displayed good antifungal and algicidal activities toward Microbotryum violaceum, Botrytis cinerea, and Septoria tritici.
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