Antimicrobial Activity of three Selective Rhizomes of Curcuma longa & Curcuma aromatica on Uropathogens of Diabetic Patients

Abstract

The present study aims to investigate the antibacterial activity of three different rhizomes of Curcumin grown in different regions of Tamil Nadu tested against the multi drug resistant Uropathogens isolated from patients with type2 DM. A common illness that affects people with diabetes is urinary tract infection. Diabetes increases the risk of UTI due to a damaged genitourinary tract. The multi-drug resistance of uropathogens to standard antibiotic therapy is a rising concern in the management of UTI in diabetes patients. A total of 120 midstream urine samples were collected using sterile uricols (Hi media pvt India Ltd) from the diabetology department of Bangalore Hospital. Urine samples were processed in lab within two hours of collection. Recent changing trends in antimicrobial resistance demands quick alternative regime for the control of frequent UTI in patients with Diabetes Mellitus. In this prospective study we investigated the rhizomes of Curcuma longa and C. aromatica commonly known as turmeric collected from three different regions of Tamil Nadu. Turmeric extracts have shown a chemo protective effect against Uropathogens. With the investigations undertaken in this study we propose the potential bactericidal activity and medicinal use of C. longa and C. aromatica. Study results indicated good antimicrobial efficacy of the wild type rhizome of C. aromatica on various multi resistant UTI pathogens of Pseudomonas aeruginosa, Methicillin resistant S. aureus, (MRSA) Vancomycin resistant Enterococcus Faecalis, (VRE) and E. coli.