Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes

Hakan Arslan,Gulay Borekci,Cevdet Akbay,Cemal Koray Ozer,Nizami Duran

doi:10.3390/molecules14010519

Hakan Arslan, Gulay Borekci + Show 3 more

Open Access

https://doi.org/10.3390/molecules14010519

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Abstract

Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.

Highlights

Industrial production and the use of Fe, Co, Cu, Ni, Zn, Cd, and Pb elements can cause environmental pollution
The in vitro antimicrobial properties against a number of Gram positive and Gram negative bacteria, and yeasts of both ligands and their metal complexes are presented in Tables 1-3, respectively
It is interesting to note that the investigated compounds with cyclohexane group show lower antimicrobial activity. This behavior can be attributed to the fact that due to their low lipophilicity, these compounds do not penetrate into the microorganisms as as the thiourea derivatives with benzyl group do

Summary

Introduction

Industrial production and the use of Fe, Co, Cu, Ni, Zn, Cd, and Pb elements can cause environmental pollution. [L1], N-(di-n-propylcarbamothioyl)cyclohexane carboxamide [L ] di-n-butylcarbamothioyl)cyclohexanecarboxamide [L3], N-(diphenylcarbamothioyl) cyclohexanecarboxamide [L4], N-(morpholine-4-carbonothioyl)cyclohexanecarboxamide [L5]) and their Ni2+ and Cu2+ metal complexes against standard bacterial (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus, Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and yeast strains (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). In the light of interesting antimicrobial activities of the coordination complexes, the thiourea derivative ligands and their Ni2+ and Cu2+ metal complexes were screened for antibacterial and antifungal activity against S. aureus, S. epidermidis, E. faecalis, S. pyogenes, B. cereus, B. cereus, E.

Results

Conclusion