Antimicrobial activity of secondary metabolite compounds from lichen Teloschistes flavicans

Abstract

Exploration of lichen natural compounds has attracted a lot of attention from researchers as potential medicinal raw materials because chemical compounds contained in lichen have many properties. The potential for developing secondary metabolite compounds of lichen has become a trend for various benefits, for example, in cosmetics, agriculture, health, and food. Lichen Teloschistes flavicans was a concern to study because there were not many reports of secondary metabolites that have antimicrobial activity. The research objective was to examine antimicrobial activity using 3-[1’-(2”,3”-dihydroxy-phenyl)-propyl]-7hydroxy-chroman-4-one compound from lichen Teloschistes flavicans. The antimicrobial activity test was a well diffusion method. Bioactivity was determined by calculating the clear zone formed around the well. Antimicrobial activity testing indicated the inhibition of bacterial growth at a concentration of 500 ppm and 1000 ppm with the respective inhibition zones namely E. coli (10-11 mm), S. Typhi (2-5 mm), K. pneumoniae (11-13 mm), and S. aureus (10-13 mm). Also, B. cereus bacteria and C. albicans fungi were only inhibited at a concentration of 1000 ppm with an inhibition zone of 6 mm each. This research provides scientific knowledge about the potential development of lichen T. Flavicans as an antimicrobial.