Antimicrobial activity of plant-extract-mediated synthesis of Silver-Zinc Oxide nanocomposites and their acaricidal efficacy on Hyalomma marginatum ticks

Abstract

BackgroundNanocomposite materials have received a lot of attention recently, and interest at the academic and industrial levels because they have better qualities than single nanoparticles of metal, particularly the bio-fabricated type that is more environment-friendly. AimThe main goal of this investigation is to determine whether the leaf extract of Lawsonia inermis can be applied as a reducing and stabilizing material in the production of Ag-ZnO nanocomposite (NCs). Additionally, to investigate the probable biological actions of these Ag-ZnO-NCs. MethodologyAg-ZnO nanoparticles were synthesized using L. inermis leaves’ extract. The synthesized nanoparticles were characterised using an Emission-Scanning Electron Microscope (SEM), Energy-Dispersive X-ray spectroscopy and X-ray diffraction. Ag-ZnO-NCs were additionally evaluated for their acaricidal, antibacterial, and antifungal performance, and hemocompatibility properties. ResultsThe findings have proven that the Ag-ZnO-NCs were crystalline at the nanoscale with particle sizes between 20 and 160 nm. The Ag-ZnO-NCs revealed acaricidal activity against Hyalomma marginatum and showed effective antibacterial action as opposed to Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, minimum inhibitory concentration (100 μg/ml). Moreover, The Ag-ZnO-NCs exhibited significant antifungal activity to Aspergillus flavus as well as A. niger. ConclusionThe present work pointed out that the L. inermis fresh leaf was an effective material for the fabrication of Ag-ZnO-NCs which showed critical biological potency and appeared hemocompatible.