Abstract
Throughout the genetic and physiological evolution of microorganisms, the microbiological sciences have been expanding the introduction of new therapeutic trials against microbial diseases. Special attention has been paid to the bacterium Helicobacter pylori, which induces gastric infections capable of causing damage, ranging from acute and chronic gastritis to the development of gastric cancer and death. The use of compounds with natural origins has gained popularity in scientific research focused on drug innovation against H. pylori because of their broad flexibility and low toxicity. The aim of this study was to describe the use of natural products against H. pylori in order to clarify important parameters for related fields. The study demonstrated the vast therapeutic possibilities for compounds originating from natural sources and revealed the need for innovations from future investigations to expand the therapeutic arsenal in the fight against H. pylori infection.
Highlights
The relationship between Helicobacter pylori and acquired resistance to various drugs from conventional therapy is of worldwide concern
The first “Asian-Pacific H. pylori Consensus Conference” took place in Singapore in August 1997, and since new scientific information concerning the treatment of infection by this bacterium has been published along with updates from conferences in North America and Europe [2]
Given the numerous benefits provided by natural products according to the literature, this paper presents a bibliographical survey of reports of antimicrobial action exerted by them against Helicobacter pylori published between the years 1996 and 2013, with the purpose of detailing publications of great importance to the scientific community
Summary
The relationship between Helicobacter pylori and acquired resistance to various drugs from conventional therapy is of worldwide concern. Studies with the aim to elucidate the anti-Helicobacter pylori profile presented by essential oils have been developed in recent years because of the need for further drug options in the treatment of disorders arising from this type of infection. This fact is justified by the increased number of strains resistant to the standard drug therapy used in clinical practice, such as clarithromycin, the drug most frequently used as a therapeutic agent, and the lack of an ideal drug regimen with 100% safe applicability [8]. The results were able to attribute limonene as the main compound responsible for the anti-Helicobacter pylori activity
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