Abstract
Objective: The objective of this study was to evaluate the antimicrobial activity of methanolic extract of Ludwigia parviflora L. using standard bacterial strains and compare its activity with that of standard antibiotics.
 Methods: The antibacterial activity and antibiotic susceptibility tests were done by disk diffusion method using MTCC bacterial strains.
 Results: The study revealed that the methanolic extract of the whole plant of L. parviflora L. was effective to inhibit the growth of Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Among the tested strains, S. aureus, P. aeruginosa, K. pneumoniae, and E. coli were more susceptible to the methanolic extract of L. parviflora than the commonly using antibiotic tetracycline 30 mcg. The activity of methanolic extract was also higher than the activity of gentamicin 10 mcg against the P. aeruginosa.
 Conclusion: The study concluded that the crude methanolic extract of the whole plant of L. parviflora L. is a good source for antibacterial agent against S. aureus, P. aeruginosa, K. pneumoniae, and E. coli. Hence, this plant can be used as a natural alternative to the common antibiotics such as gentamicin and tetracycline against common bacterial infections after validating its pharmacological and toxicological activities.
Highlights
Plants have been used as a source of medicine in traditional or folk medicine from time immemorial due to their magical power to cure diseases [1]
The present study suggests that the methanolic extract of the whole plant of L. parviflora possesses powerful antibacterial activity against S. aureus, P. aeruginosa, K. pneumoniae, and E. coli
Since the methanolic extract of the whole plant of L. parviflora showed promising activity against all the tested bacterial strains, the present study suggests that this plant can be taken into consideration for isolating the active principle to develop a new broad-spectrum antibiotic against the common pathogenic bacteria and would be used as a more powerful alternative to the common antibiotics, tetracycline and gentamicin (Fig. 2)
Summary
Plants have been used as a source of medicine in traditional or folk medicine from time immemorial due to their magical power to cure diseases [1] They contain nutrients and chemicals for providing health benefits. Researchers have given more attention to discover new antimicrobial drugs of plant origin because most of the available synthetic antibiotics are losing their capacity to inhibit the growth of microorganisms [5,6]. This is mainly due to the ability of microorganisms to develop resistance against the continuously using antibiotics [7,8]. This study is focused to validate the antimicrobial activity of Ludwigia parviflora L. against standard bacterial strains and to compare its activity with that of standard antibiotics for suggesting a natural alternative to the commonly available antibiotics
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