Abstract
Background and Aim: The increasing antimicrobial resistance with reduced susceptibility to antimicrobial drugs is becoming a major concern for both human and animal, which raises health morbidity and mortality rate of cases that cannot be treated by antibiotics. Nowadays, there are many efforts to minimize the misuse of antibiotics. This study evaluated the antimicrobial activity of the crude ethanolic extracts of three Thai herbs divided in four groups; petals of marigold (Tagetes erecta), mulberry leaves and root barks (Morus indica), and whole onions of red shallot (Allium ascalonicum) against Streptococcus agalactiae. Materials and Methods: The antimicrobial activity of four groups of the crude extracts using absolute ethanol from three Thai herbs was tested against standard strains of S. agalactiae using the agar well diffusion method. The commercial antibiotics ceftriaxone and erythromycin were used as positive control standards to determine the sensitivity of S. agalactiae. Results: The result showed that all four groups of Thai herbal extract had inhibitory activity against standard strains of S. agalactiae. The inhibitory concentration test values were obtained using the dilution test at 25, 50, and 75 mg/ml. The maximum antimicrobial activity against S. agalactiae was observed in the ethanolic extracts from red shallot extract, followed by leaves of mulberry, petals of marigold, and root barks of mulberry, respectively. Conclusion: The results demonstrated that the crude extract of three Thai herbs had antimicrobial activity inhibiting the growth of S. agalactiae and suggesting that they may be useful in the treatment of S. agalactiae infections in humans and animals.
Highlights
Streptococcus agalactiae is a Gram-positive bacteria, which is classified in Group B streptococcus
This study evaluated the antimicrobial activity of the crude ethanolic extracts of three Thai herbs divided in four groups; petals of marigold (Tagetes erecta), mulberry leaves and root barks (Morus indica), and whole onions of red shallot (Allium ascalonicum) against Streptococcus agalactiae
The result showed that all four groups of Thai herbal extract had inhibitory activity against standard strains of S. agalactiae
Summary
Streptococcus agalactiae is a Gram-positive bacteria, which is classified in Group B streptococcus It can be found as microbiota in the gastrointestinal tract of both humans and animals, especially in female animals [1]. It is usually associated with many infective diseases of neonatal animals such as meningitis and septicemia after pregnant animals have experienced traumatic damage during parturition. It causes a significant veterinary problem since S. agalactiae is recognized as the main bacterial pathogen of bovine mastitis in dairy cows by infecting the mammary glands of ruminants [2,3,4]. This study evaluated the antimicrobial activity of the crude ethanolic extracts of three Thai herbs divided in four groups; petals of marigold (Tagetes erecta), mulberry leaves and root barks (Morus indica), and whole onions of red shallot (Allium ascalonicum) against Streptococcus agalactiae
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