Antimicrobial activity of long-chain ( E)-3-alken-2-ones

Abstract

( E)-3-Tridecen-2-one, a compound identified from the interdigital glands of black-tailed deer ( Odocoileus hemionus columbianus), has been shown to inhibit the growth of bacteria and fungi. Homologues of ( E)-3-tridecen-2-one were prepared and screened for antimicrobial activity. For the fungus, Trichophyton mentagrophytes, the minimum inhibitory concentration (MIC) of (E)-3-Tetradecen-2-one was 12.5 μg/mL, and for the bacteria, Propionibacterium acnes, the MIC of (E)-3-heptadecen-2-one was 3.13 μg/mL.