Abstract
Multi-drug resistance patterns in bacteria are difficult to treat. The search for a new alternative antibiotic drug that may help to control drug-resistant pathogenic bacteria is necessary. The present study focused on the antibacterial effect of Lantana camara extracts against pathogenic bacteria. Extraction was performed on L. camara leaves and stems using the maceration technique. Three extraction solvents were used. The experiments were carried in duplicate, and the results were statistically analyzed with SPSS. Tannins, phenols, saponins, alkaloids, flavonoids, and glycosides were found in L. camara plant. Methanol leaf extract possessed greater antimicrobial potential than petroleum ether and water extracts with maximum inhibition zone belonging to S. aureus 43300 (DIZ = 28 mm). The methanol stem extract of L. camara showed the best activity against S. typhi (DIZ = 15 mm). The results for both L. camara leaves and stem extracts were analyzed, and both showed a significant difference among the extracts with P-values < 0.05. The lowest MIC against S. aureus 43300, S. typhi, and P. aeruginosa was 50 mg/ml. In search for a synergetic effect between paracetamol and L. camara extracts, positive results were viewed against E. coli, S. typhi B69, and S. typhi B71.
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