Abstract
Agar well diffusion method was used to evaluate the antimicrobial potential of Justicia neesii extract. The maximum activity index (AI) values are observed against Klebsiella pneumonia (1.208) and low AI value for Streptococcus faecalis (0.963) compared to other bacterial species. The maximum AI values are observed against Saccharomyces cerevisiae (1.147) and low AI value for Fusarium axisporum (0.986) compared to other fungal species. The MIC and MBC/MFC values indicated the bacteriostatic/ fungistatic nature of the extract and also having good correlation with the zone of inhibition values. The total activity values indicated that J. neesii extract can show antimicrobial activity even at higher dilutions, except for Gram negative bacteria.
Highlights
Wide range of plants from tropical and sub-tropical regions of India were reported to posses antimicrobial properties (Prasannabalaji et al, 2012)
The activity index values are helpful in estimating the potential of antimicrobial activity quantitatively compared to the respective standards
The plant extract has shown higher activity index (AI) values against Gram negative bacteria which means that the extracts are having good activity against the Gram negative bacteria compared to the standard
Summary
Wide range of plants from tropical and sub-tropical regions of India were reported to posses antimicrobial properties (Prasannabalaji et al, 2012). J. neesii is one of such plant belongs to the family Acanthaceae grows in tropical regions of India as a small tropical herb. In the previous studies on this plant reported the presence of various types of lignans. Three β-apolignans including 1,4-dihydotaiwanin C, jusneesiin, jusneesiinol (Rajasekhar, 1998) and two arylnaphthalide lignans including jusmicranthin and justirumalin are found to be present (Rajasekhar, 1999; Gopalaiah, 2001). The plant was found to contain diphyllin glycosides like neesiinoside A and neesiinoside B (Subbaraju, 2001). The review of scientific literature reviled that there is no significant pharmacological work done on J. neesii. It was consider worthwhile to elucidate the antimicrobial properties of J. neesii plant extracts
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