Abstract
Dutsen dan Libya is a rock material used in traditional medicine for the treatment of a myriad of ailments like cold, fever, stomach disorder, diarrhea and Jaundice. To evaluate the scientific basis for the use of the rock, the antimicrobial activities of its water extract was studied against some common gram positive and gram negative bacteria and fungi. The antimicrobial activity of the aqueous extract was evaluated by determination of the diameter of zone of inhibition using the paper disk diffusion method. Results showed sensitivity to Pseudomonas aeruginosa, Streptococcus pyogenes, Staphylococcus aureus, Corynebacterium ulcerans, Klebsiella pneumoniae and Candida albicans. Bacillus subtilis, Salmonella typhi, Escherichia Coli and Neisseria gonorhoea were resistant. Studies on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the rock-extract solution on the test organisms showed the lowest MIC at the dose level of 1.25mg/ml and MBC at the dose level of 2.50mg/ml respectively against Pseudomonas aeruginosa and Streptococcus pyogenes. The highest MIC (2.5 mg/ml) and MBC (5.00mg/ml) were exhibited against staphylococcus aureus, corynebacterium ulcerans, klebsiella pneumoniae and Candida albicans.KEYWORDS: Antimicrobial, Infectious disease, Pathogenic, Bacteria, Fungi
Highlights
Infectious disease is one of the causes of death worldwide
The results of the antimicrobial activities, the zone of growth inhibition in millimeters, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests carried out on the various microorganisms are presented in the following Tables 1, 2, 3, and 4 respectively
The results of this study show that water extract of this rock has demonstrated significant antimicrobial activities against the tested microbes
Summary
Infectious disease is one of the causes of death worldwide. It accounts for approximately 50% of death in tropical countries (Iwu et al, 1999). This may be due to poverty and increasing incidence of multiple drug resistance. Bacterial resistance to almost all antimicrobial agents has been reported (Truiti et al, 2003). This resistance is due to indiscriminate use of antimicrobial drugs commonly used in the treatment of infectious diseases (Afolayan and Aliero, 2006). There is, a serious need to develop new antimicrobial agents that are effective with minimal side effects
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
