ANTIMICROBIAL ACTIVITY OF DATE PALM (PHOENIX DACTYLIFERA) PITS EXTRACTS AND ITS ROLE IN REDUCING THE SIDE EFFECT OF METHYL PREDNISOLONE ON SOME NEUROTRANSMITTER CONTENT IN THE BRAIN, HORMONE TESTOSTERONE IN ADULTHOOD

Abstract

The present work was carried out to study the impact of date palm pits as antibacterial activities on two species of pathogenic bacteria (klebsiella pneumonia and Escherichia coli) and its role in reducing side effect of methylprednisolone on the some neurotransmitter content in the brain, hormone testosterone and testclture of male albino rats .Date palm pits is most effective in inhibiting growth of bacteria as compared with antibiotics due to differences in resistance of bacteria to anti-tested materials due to change in membrane permeability of cells, thereby hindering the entry of enzymes or excreted by the change in the chemical composition of the constituent chemical. The results showed that the daily oral administration of pits of date palm caused the maximal increase in NE, DA& GABA content was found in the brain stem after 2 weeks. The daily oral administration of methylprednisolone caused decrease in NE,DA& GABA content was found in the brain stem after 2 weeks. Moreover, the daily oral administration of pits of date palm and methylprednisolone caused increase in NE content was found in the brain stem after 2 weeks. The daily oral administration of pits of date palm and methylprednisolone caused a significant increase in testosterone level in serum blood of male albino rat. From the present results, it is clear that Effect of chronic oral administration of methylprednisolone and pits of data palm on testicular of male albino rat caused recovery effect, notice high sperm in some tubules and tubular partial late spermatogenic arrest (spermatide level) is only seen in 10-20% of tubules. The appropriate recommendations in this study to use nuclei dates Antimicrobial on klebsiella pneumonia and Escherichia coli than the activity of standard antibiotics and the results concluded that using intended dates date palm pits as a preventive measure to reduce the side effects resulting from the use of a drug methylprednisolone on the some neurotransmitter content in the Brain. Hormone Testosterone and testclture in male albino rats. Key word: Pits of Date Palm (Phoenix dactylifera) , Antimicrobial, Methyl prednisolone, klebsiella pneumonia , Escherichia coli, Neurotransmitter content. INTRODUCTION The date palm (Phornix dactylifera L.) is considered the most important source of food for both human in arid and semiarid (Besbes et al., 2004). Dates contain a high percentage of sugars reaching 88% in some varieties ( Al Shahib and Marshall,2003). Dates are also rich in mineral salts and vitamins (Booij et al.,1992). For the date pit, the percentage of non-reducing sugars is 3.82% and in glucose and fructose is 1.68 and 1.53, respectively (Fayadh and AlShowiman,1990). In local medicinal practices, dates are considered a tonic. Some consider it to be an aphrodisiac. The flower of the plant is used as a purgative ( Zohget et al.,2000). Experimentally, date extracts have been shown to increase sperm count in guinea pigs and to enhance spermatogenesis and increase the concentration of testosterone, follicle stimulating hormone, and luteinizing hormone in rats ( El-Mougy et al., 1991). Date palm pollen(DPP) cure