Abstract
Bacillus subtilis produces lipopeptides biosurfactant that have a great potential for biotechnological and biopharmaceutical applications, and Surfactin is the most potent lipopeptide biosurfactant known. In this work, the lipopeptide biosurfactant produced by Indonesian marine bacteria, B. subtilis C19, was analyzed. After 300 h cultivation in defined medium, a crude biosurfactant concentration of 2 g/L was produced. Biosurfactant product characterization have revealed high stability product in the wide range variation of pH and salinity. The antimicrobial activity evaluation of biosurfactant against 6 human pathogenic microbes (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica Typhi, Listeria monocytogenes, and Candida albicans), demonstrated that biosurfactant produced by B. subtilis C19 have a specific antimicrobial activity. It could inhibit growth of C. albicans without inhibiting both gram-positive and gram-negative bacteria; therefore it could be promoted as antifungal active agent.
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